deferoxamine decreases levels of iron sucrose by inhibition of GI absorption. Manage and view all your plans together even plans in different states. Give each dose as 750mg for a total cumulative dose not to exceed1500mg of ironper course. Pediatric Patients: The most common adverse reactions (2%) are headache, respiratory tract viral infection, peritonitis, vomiting, pyrexia, dizziness, cough, nausea, arteriovenous fistula thrombosis, hypotension and hypertension. Administer Venofer early during the dialysis session (generally within the first hour). * Adapted from the KDIGO Clinical Practice Guideline for Anemia in Chronic Kidney Disease. Iron deficiency can occur at any stage of life, due to physiological demands, for example, during pregnancy, childhood growth or prolonged periods of sickness. Avoid or Use Alternate Drug. 2 DOSAGE AND ADMINISTRATION 2.1 Recommended Dosage Recommended dosage for patients weighing 50kg (110lb) or more: Give Injectaferin two doses separated by at least 7 days. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. If we don't have the calculator you need we'll try to make it for you and add it to the website. A patients lean body weight (or actual body weight if less than lean body weight) should be utilized when determining dosage. Use Caution/Monitor. Fill in the calculator/tool with your values and/or your answer choices and press Calculate.
FERAHEME Dosing & Administration - Feraheme Minor/Significance Unknown. Canada residents can call a provincial poison control center. The dosing for iron replacement treatment in pediatric patients with hemodialysis-dependent chronic kidney disease (HDD-CKD), non-dialysis-dependent chronic kidney disease (NDD-CKD) or peritoneal-dialysis-dependent chronic kidney disease (PDD-CKD) has not been established. When administered via infusion, dilute up to 750 mg of iron in no more than 250 mL of sterile 0.9% sodium chloride injection, USP, such that the concentration of the infusion is not less than 2 mg of iron per mL and administer over at least 15 minutes. Venofer must only be administered intravenously either by slow injection or by infusion. Chandler G, Harchowel J, Macdougall I.
Clinical calculators for obstetrics and gynaecology - calculosaurus Pain, swelling, or redness at the injection site may occur. https://www.uptodate.com/ (Requires subscription). Use Caution/Monitor. Multiple placebo-controlled, randomized clinical trials have been conducted with IV iron in patients with New York Heart Association class II-III heart failure with an ejection fraction 45% who met criteria . Before using, check this product visually for particles or discoloration. 2010;18(3). If you log out, you will be required to enter your username and password the next time you visit. Congenital Pulmonary Airway Malformation Volume Ratio (CVR) Calculator -. Modify Therapy/Monitor Closely. Use Caution/Monitor. It varies from increases in dietary intake of iron (usually for prophylaxis purposes) to oral, intramuscular or intravenous therapy. If you have private insurance, Venofer or Monoferric may be on the list of covered medications. Severe adverse reactions including circulatory failure (severe hypotension, shock including in the context of anaphylactic reaction) may occur in pregnant women with parenteral iron products (such as Venofer) which may cause fetal bradycardia, especially during the second and third trimester. Next Steps Evidence Creator Insights Dr. Andreas M. Ganzoni About the Creator sodium citrate/citric acid will decrease the level or effect of iron sucrose by increasing gastric pH. The therapeutic management of IDA focuses on the replenishment of the iron stores through methods that have been mentioned above. Avoid or Use Alternate Drug. ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Dosing for patients who weigh 50 kg or more For patients weighing 50 kg (110 lb) or more: Give Injectafer in two doses separated by at least 7 days. Use Caution/Monitor. * Calculators are available in UpToDate to determine ideal body weight and lean body weight. Am J Hosp Pharm. The recommendation is that most adults need a cumulative dose of elemental iron of at least 1 g. Iron replenishment can be done intravenously, either as total dose (example: iron-dextran or iron carboxymaltose) or as split dose (example: iron sucrose).
Treatment of iron deficiency anemia in adults - UpToDate The usual total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. Copyright 1993-2021 There is in depth information below the form on the method used and on the result provided.
Intravenous iron sucrose for children with iron deficiency anemia: a Accessed: 4/12/2011. Serious - Use Alternative (1)iron sucrose decreases levels of mycophenolate by inhibition of GI absorption. VenAccess is a trademark of Vifor (International) Inc. Switzerland. Use Caution/Monitor. Koch TA, Myers J, Goodnough LT. Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Serious - Use Alternative (1)iron sucrose will decrease the level or effect of baloxavir marboxil by cation binding in GI tract. Monitor Closely (1)iron sucrose decreases levels of liothyronine by inhibition of GI absorption. Applies only to oral form of both agents. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Most studies have used IV iron sucrose (maximum dose of 200 mg per setting) or ferric carboxymaltose (maximum dose of 1000 mg per week).
PDF Iron Sucrose: Guidelines for Administration Document Type: Guideline Applies only to oral form of both agents. Applies only to oral form of both agents. Use Caution/Monitor. calcium citrate decreases levels of iron sucrose by inhibition of GI absorption. DOSAGE AND ADMINISTRATION: Venofer must only be administered intravenously either by slow injection or by infusion.
PDF PRODUCT MONOGRAPH - pdf.hres.ca 2012;2(4):288-335. Where C= concentration of elemental iron (mg/ml) in the product being used: Data from Ferrlecit postmarketing spontaneous reports indicate that individual doses exceeding 125 mg may be associated with a higher incidence and/or severity of adverse events, Adult Patients with Hemodialysis Dependent-Chronic Kidney Disease (HDD-CKD), Adult Patients with Non-Dialysis Dependent-Chronic Kidney Disease (NDD-CKD), WARNING: RISK FOR SERIOUS HYPERSENSITIVITY/ANAPHYLAXIS REACTIONS, Iron Deficiency and Anemia- signs and therapeutic options. Avoid or Use Alternate Drug. Monitor Closely (1)famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. 3) Bayraktar UD, Bayraktar S. (2010) Treatment of iron deficiency anemia associated with gastrointestinal tract diseases. The Ganzoni equation used by the iron deficiency calculator is the following: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores. Symptoms associated with Venofer total dosage or infusing too rapidly included hypotension, dyspnea, headache, vomiting, nausea, dizziness, joint aches, paresthesia, abdominal and muscle pain, edema and cardiovascular collapse. Anemia caused by the depletion of iron is called iron deficiency anemia. This drug is available at a middle level co-pay. official version of the modified score here.
Calculosaurus | Ferinject dose calculator FERAHEME vs Venofer (iron sucrose) - Feraheme By entering this website, you acknowledge that you are a licensed healthcare professional practicing in the United States. Do not dilute to concentrations below 1 mg/mL [see How Supplied/Storage and Handling (16.2).] Minor/Significance Unknown. Since this is less than the threshold of total dose of 20 mg/kg, the deficit can be eliminated with a single infusion. Dr. Ganzonis primary research is focused on iron deficiency and plasma iron transport. Minor (1)iron sucrose decreases levels of manganese by inhibition of GI absorption. Crown Rump Length and Nuchal Translucency. Adult Patients with Non-Dialysis Dependent-Chronic Kidney Disease (NDD-CKD): Administer Venofer 200 mg undiluted as a slow intravenous injection over 2 to 5 minutes or as an infusion of 200 mg in a maximum of 100 mL of 0.9% NaCl x 15 minutes. 1988 May;111(5):566-70. Avoid or Use Alternate Drug. Oral and parenteral products - see background option for oral products. When iron sucrose was administered at deliberate overdoses to rabbit dams (up to 215 mg/kg/day) marked fetal/placental iron overload was noted. Use Caution/Monitor. Applies only to oral form of both agents. iron sucrose decreases levels of tetracycline by inhibition of GI absorption. Venofer (iron sucrose injection, USP) For Intravenous Use Only INDICATION AND USAGE Venofer (iron sucrose injection, USP) is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). Applies only to oral form of both agents. [. FERAHEME was non-inferior to Venofer (iron sucrose) in mean Hgb rise from baseline 2,5. Use Caution/Monitor. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. Applies only to oral form of both agents. 1) Ganzoni AM. Applies only to oral form of both agents. Use Caution/Monitor.
Venofer (iron sucrose) 20 mg iron / ml, solution for injection or Applies only to oral form of both agents. Avoid or Use Alternate Drug. Patients diagnosed with iron deficiency are prescribed iron supplementation, either to replete body stores or to correct anemia. Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. Where C= concentration of and formulary information changes. 200-800 mg/kg (2-8 mL/kg) every 3-4 weeks. Equations : Total body iron deficit (mg) = body weight (kg) x (target Hb - actual Hb in g/dL) x 2.4 + iron depot (mg)** [1, 2] Iron depot: 15 mg/kg for body weight less than 35 kg 500 mg for those with a body weight greater than or equal to 35 kg Ideal Body Weight (kg) =45.5 +2.3 * (height inches - 60 inches) [3] Do not mix iron sucrose with other medications or TPN solution. Manufacturer advises for slow intravenous injection ( Venofer ), give undiluted at a rate of 1 mL/minute; do not exceed 10 mL (200 mg iron) per injection. Initial symptoms may include hypotension, syncope, unresponsiveness, cardiac/cardiorespiratory arrest. Human studies not conducted. The dosage of Venofer is expressed in mg of elemental iron. IMPORTANT SAFETY INFORMATION DOSAGE AND ADMINISTRATION Pediatric Patients (2 Years of Age and Older) 3) Auerbach M, Witt D, Toler W, Fierstein M, Lerner RG, Ballard H. (1988) Clinical use of the total dose intravenous infusion of iron dextran. HOW TO USE: This medication is given by injection into a vein as directed by your doctor. Adult Patients: The most common adverse reactions (2%) include diarrhea, nausea, vomiting, headache, dizziness, hypotension, pruritus, pain in extremity, arthralgia, back pain, muscle cramp, injection site reactions, chest pain and peripheral edema. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every two weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. The Ganzoni equation is: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores In most cases, adult patients require a cumulative dose of elemental iron of at least 1 g. Most commonly, iron replenishment therapy is done intravenously: As total dose (iron-dextran or iron - carboxymaltose);
Venofer / Products / American Regent Results: Twelve children (6 females) aged 1.2-14 years (median age 8.9 years) received at least one dose of . Minor/Significance Unknown. . Reactions have occurred following the first dose or subsequent doses of Venofer. Either increases effects of the other by pharmacodynamic synergism. Applies only to oral form of both agents. There is limited experience with administration of an infusion of 500 mg of Venofer, diluted in a maximum of 250 mL of 0.9% NaCl, over a period of 3.5 to 4 hours on Day 1 and Day 14 [see How Supplied/Storage and Handling (16.2). Use Caution/Monitor. Calculates iron deficit for dosing iron. For additional Safety Information, please see Full Prescribing Information. Applies only to oral form of both agents. Evaluate the hematologic response (hemoglobin, ferritin, iron and transferrin saturation) at least one month following the second Feraheme infusion. Separate by 2 hr. The dosage of Venofer is expressed in mg of elemental iron. This information does not assure that this product is safe, effective, or appropriate for you. Applies only to oral form of both agents. Compare formulary status to other drugs in the same class. Iron deficit - equation derivation: Assumptions: -Blood volume = 65 mL/kg -Hemoglobin conc target =14.0 g/dL -Deficits in body stores are ignored. Most Shirley, NY: American Regent, Inc.; 9/2020. WARNING: RISK FOR SERIOUS HYPERSENSITIVITY/ANAPHYLAXIS REACTIONS Fatal and serious hypersensitivity reactions including anaphylaxis have occurred in patients receiving Feraheme. For patients receiving hemodialysis, administer Feraheme once the blood pressure is stable and the patient has completed at least one hour of hemodialysis. No additional iron to replenish stores. The recommended Feraheme dose may be readministered to patients with persistent or recurrent iron deficiency anemia. Monitor Closely (1)cimetidine will decrease the level or effect of iron sucrose by increasing gastric pH. There are three fields in the parenteral iron replacement for iron deficiency anemia calculator: Weight can be input in either lbs or kilograms and the required transformations are performed by the calculator. This drug is available at the lowest co-pay. iron sucrose decreases levels of ciprofloxacin by inhibition of GI absorption. J Lab Clin Med; 111(5):566-70. Observed Hb = the patients current hemoglobin in g/dl. 1. Hemodialysis-dependent CKD: 100 mg elemental iron IV (injection or infusion over 2-5 min) per dialysis session not to exceed total cumulative dose of 1000 mg divided in 3 doses/week. Diagnosis and management of iron deficiency anaemia: a clinical update. J Med. Do Not Copy, Distribute or otherwise Disseminate without express permission. Applies only to oral form of both agents. We comply with the HONcode standard for trustworthy health information. Use Caution/Monitor. Assure stable intravenous access to avoid extravasation. Situation Analysis Market Size MAT Sales Cr LC MAT Share % MAT Gr % Total Pharma Market 9388.69 100 13.5 Iron Sucrose 11.18 93.81 37.65 Brand Company Saline MAT . Have resuscitation equipment and personnel trained in the detection and treatment of anaphylactic-type reactions readily available during INFeD administration.
Calculation of Iron Deficit - Perinatology.com Individual plans may vary Monitor Closely (1)esomeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. The dosage of iron sucrose is expressed in mg of elemental iron. Discuss the risks and benefits with your doctor.This medication passes into breast milk. The weight of the patient is taken into account in order to estimate iron stores, while haemoglobin is required as both current measured and target. Most Minor/Significance Unknown. Applies only to oral form of both agents. Indications: Ferrlecit is an iron replacement product for treatment of iron deficiency anemia in adult patients and in pediatric patients age 6 years and older with chronic kidney disease receiving hemodialysis who are receiving supplemental epoetin therapy. iron sucrose increases levels of calcium acetate by enhancing GI absorption. Mean Corpuscular Hemoglobin Concentration (MCHC) Calculator, Red Blood Cell (RBC) Indices Calculator, Iron Deficiency In Pregnancy Calculator. Applies only to oral form of both agents. A patients lean body weight (or actual body weight if less than lean body weight) should be utilized when determining dosage. Venofer is given as an infusion into a vein. Avoid or Use Alternate Drug. Most 1995 Mar-Apr;11(2):163-8. Administer a test INFeD dose prior to the first therapeutic dose. 1 Dosing for patients who weigh less than 50 kg
PDF Venofer Guidelines for Use 2011 - University Health System The plasma ferritin level as a reliable index of body iron stores following intravenous iron dextran. calcium chloride decreases levels of iron sucrose by inhibition of GI absorption. Venofer (iron sucrose injection, USP) is a brown, sterile, aqueous, complex of polynuclear iron (III)- . DICP. Applies only to oral form of both agents. Suggested regime: Prescribing instructions Prescribing a single/first dose: 1974 Jun;31(6):592-5.
Drug Dosing in Obesity Reference Table - ClinCalc.com Interaction only with oral iron administration. 2022 American Regent, Inc.PP-VE-US-0016 (v6.0)1/2022. Iron supplements, whether administered orally, intramuscular or intravenous, are used to replenish body stores and correct anemia. )If you are using this medication at home, learn all preparation and usage instructions from your health care professional. Am J HealthSyst Pharm 2006;63:731735. Prior to and at regular intervals during parenteral iron therapy, evaluate serum iron, hemoglobin, and hematocrit. Monitor Closely (1)ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH.
Iron sucrose | Drugs | BNF | NICE Applies to didanosine chewable tablets and powder for oral solution; administer 2 hr before or several hours after didanosine oral solution or chewable tablet administration. To provide clinicians with evidence-based guidance for iron therapy dosing in patients with iron deficiency anemia (IDA), we conducted a study examining the benefits of a higher cumulative dose of intravenous (IV) iron than what is typically administered. Ferrlecit may be diluted in 100 mL of 0.9% sodium chloride administered by intravenous infusion over 1 hour per dialysis session. Applies only to oral form of both agents. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. iron sucrose decreases levels of manganese by inhibition of GI absorption. Applies only to oral form of both agents. iron sucrose increases levels of calcium carbonate by enhancing GI absorption. esomeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. in the colostrum of 10 iron deficient breastfeeding women who were 2 to 3 days postpartum and received a single dose of 100 mg of intravenous iron . Use Caution/Monitor. USES: This medicine is used to treat "iron-poor" blood (anemia) in people with long-term kidney disease. For liquid medications, also enter the value of the Medicine Concentration and choose . Replacement of iron stores found in hemoglobin, myoglobin, and enzymes; works to transport oxygen via hemoglobin, Do not mix with other medications or add to parenteral nutrition solutions for IV infusion, Do not dilute to concentrations below 1 mg/mL, Add dose to 0.9% NaCl infusion bags (PVC or non-PVC); final concentrations range is 1-2 mg of elemental iron/mL, Visually inspect for particulate matter and discoloration prior to infusion, Stable for 7 days at controlled room temperature (25C). Observed Hb = the patients current hemoglobin in g/dl. The factor 2.4 comes about from the calculation that the total iron content of hemoglobin is 0.34%, the blood volume accounts for 7% . Minor/Significance Unknown. 4)Pasricha SR, Flecknoe-Brown SC, Allen KJ, Gibson PR, McMahon LP, Olynyk JK, Roger SD, Savoia HF, Tampi R, Thomson AR, Wood EM, Robinson KL. Applies only to oral form of both agents. A target haemoglobin value is also input so iron deficit can be determined according to a specified individual target.